For an oocyte to become Prepared for fertilization and advancement into an embryo, the appropriate list of genes has to be turned on. Namekawa suspected this pre-programming of the oocyte genome comes about in several phases — the primary just one starting round the time a feminine is born. He thought that chromatin remodeling proteins did much of this operate, by shifting spools around.
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Utilizing the GCRLE grant, Munakata and Namekawa will search extra intently at how oocytes are genomically primed and saved for later use. They'll investigate the role of the chromatin remodeler in oocyte survival and fertility.
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Namekawa believes that in human oocytes, alterations in these patterns could disrupt the delicate choreography of genes becoming turned on and off at the appropriate instances — leaving them unprepared for fertilization or advancement into nutritious embryos. Changes in chromatin composition being an oocyte ages might also impression how that chromosomes segregate all through cell division.
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